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CoBot4 Precision Therapy

Cancer is more than business, it’s a mission for Europe and commitment for us:

EU missions are commitments to solve major societal challenges like fighting cancer, adapting to climate change, protecting our oceans, living in greener cities and ensuring soil health and food.

As integral part of the Horizon Europe framework programme beginning in 2021, they are a new way to deliver on these commitments.

The missions will contribute to the goals of the European Green Deal, Europe’s Beating Cancer Plan as well as the Sustainable Development Goals.

It is urgent to emphasize that cancer – as a vast group of diseases characterized by an abnormal and uncontrolled growth of cells that, in most cases, form a mass called a tumor –is the second leading cause of death worldwide. The number of cases has been growing due to a global population that is also growing and aging, and according to the prediction of the World Health Organization (WHO) it points out that cancer will kill more than 13.1 million people per year by 2030. Statistically, two out of five people born today will be diagnosed with cancer before their thirtieth birthday, effectively dying from the condition (source: WHO).

Chemotherapy continues to be a very important option in the treatment of cancer cells; however, the drugs used in it can also affect some types of fast-growing healthy cells, such as skin, hair, intestines, and bone marrow cells, leading to the appearance of side effects to the treatment. Along with low selectivity (leading to severe side effects), multi-drug resistance is also a limitation of chemotherapy. These restrictions become especially pertinent to the research and development of smart drug delivery systems, which use nanotransporters, in addition to strengthening the evidence between the present project and the topic “development of new treatments and therapies (e.g. cell, genetics, biological, pharmacological,regenerative, among others).

Indeed, nanotechnology has the potential to drastically change the paradigm in the fight against cancer, through greater carrying capacity, lower toxicity, greater guidance in drug administration, greater absorption by target sites and, ultimately, better pharmacokinetic patterns. The R&D activities proposed here focus on the use of artificial gold nanoparticles to transport cannabinoids/drug molecules to target sites. They include the use of a system powered by Artificial Intelligence (AI) for precision treatment. The system integrates ultrasound-guided imaging procedures and controlled positioning technologies to determine tumor size and location and to position the ultrasound transducer such that it focuses on target (tumor) sites.

The Research and Technological Development (R&TD) project, called CoBot4 Precision Therapy, will focus on the research, design and development of a smart drug delivery system based on Artificial Intelligence (AI), using artificial gold nanoparticles to facilitate the transport of cannabinoids/drug molecules to the target site, i.e., the tumor. The Consortium will consider ultrasound-guided imaging procedures and automated positioning technologies to determine the size and location of the tumor and thus position the ultrasound transducer in such a way that it focuses on the target site.

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